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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Zamifenacin fumarate is a synthetic small molecule and gut-selective muscarinic M3 receptor antagonist used in pharmacological research to study gastrointestinal motility. It has been shown to reduce colonic motility in preclinical studies. The fumarate salt has formula C31H33NO7, molecular weight 531.60 g/mol, CAS 127308-98-9, and is supplied at high purity for research applications.
Selective muscarinic M3 receptor antagonism.
Gut-selective activity that minimizes systemic muscarinic effects.
Demonstrated reduction of colonic motility in preclinical models.
Supplied as the fumarate salt with molecular formula C31H33NO7.
High purity suitable for research use (99.0%).
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This product is for research use only.
Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM.
Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR.
Reduces tumor growth in a dose-dependent manner in various xenografts.
Inhibits proliferation of cell lines with high HER-2 levels.
Arrests cell cycle at G1-S phase in BT474 cells.
Inhibits MAPK and Akt phosphorylation.
Down-regulates cyclin D1 levels and induces p27.
Inactive in MX-1 and MCF-7 xenografts.
Inhibited phosphorylation of HER-2 in BT474 xenografts.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More